Well, since you didn't put any numbers behind what you said....I will take a shot in the dark. Please make sure you using the latest templates. There was alot of optimizing done for large results sets a while back so please make sure if this first.
If you are doing just selects, you could create a View and use that to do selects from. If you are wanting to do Insert / Updates etc to the table, you would have to jump through hoops to get this to work good with a View. You do not have the ability to save from a View. You get back to either writing some custom procs to save from the View, or retrieving the entity in the end anyway to insert / update. This could defeat the purpose of using the view if you have to retrieve in the end anyway.
Also, if changing the data model is optional, you could move the unecesary columns to a one - one table. I am not a big fan of one - one tables, but in this case I might think about it in order to optimize code.
I think those are you options. I am 98% sure that there is not a way to exclude columns from a table in Nettiers. I think the above are you only options.
Jeff
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